4 Things to Secure in a Locking Box for Medicine (Plus 3 Not To)

Keeping potentially dangerous medications unsecured could have devastating consequences. Discover 4 that things need to be secured in a locking box for medications.

Accidental medicine poisoning or prescription drug misuse can be devastating to families. Among young children, 95% of medication-related poisoning visits to the ER were caused by the child ingesting medication while unsupervised. Safe medicine storage is critical to keeping your family safe.

Here are a few medications to consider securing in a lockbox to help keep your loved ones safe.*

4 Medications to Keep in a Locking Box

Opioids

Among people aged 12 and older, 2.4%, approximately 6.9 million people, misused opioids in the past year, according to a survey by SAMHSA. And in 2022, opioid overdose deaths hit an all-time high, with one occurring in the United States nearly every five minutes. The impacts of opioid misuse and addiction can be devastating. Help keep your household safe by securing any prescription opioids in a medication locking box.

Anti-Anxiety Medications

Some anti-anxiety medications like Benzodiazepines, also called Benzos, can come with a risk of dependency and withdrawal when used inappropriately. The rate of overdose deaths involving Benzos increased 8 times from 2002 to 2016. 75% of these deaths involved combined opioid use. If you have one of these medications in the house, it’s critical to make sure you’re using it as prescribed and storing it securely locked away in a medication lockbox.

Sleep Aids

Certain sleep aids like Ambien, Lunesta, Rozerem, and Sonata can have serious side effects, including potentially life-threatening allergic reactions, hallucinations, and more. Medications like these can be less habit-forming than Benzos, but over time they still may cause some physical dependence. Sleep aids can also be dangerous when mixed with alcohol, as the combination could cause a person to stop breathing. Keeping these medications locked away can help discourage inappropriate use.

Medicinal or Recreational Marijuana

In 2020, 17.9% of people 12 and older used marijuana, according to data from SAMHSA. Furthermore, 40 US states, three territories, and the District of Columbia have legalized the medical use of marijuana by adults, and 25 of those have also legalized its recreational use.

Cannabis poisoning can be dangerous for children and pets, causing symptoms like difficulty breathing, walking, or sitting up. To help prevent poisoning, keeping any cannabis secured in a lockbox is vital.

What Shouldn’t Be In Your Medication Lockbox

While many medications should always be stored up and away, out of children’s reach, there are certain medications you may need quick access to in an emergency. Because of this, you may not want to lock every medication in your lockbox. Medications to keep out can include:

  • EpiPens, which you may need quick access to in the event of a life-threatening allergic reaction.
  • Rescue inhalers for asthma attacks or other lung conditions.
  • Under-the-tongue nitroglycerin tablets for heart attacks.

These medications should be kept out of the reach of children, pets, and other household members but in a place immediately accessible in case of an emergency.

If you don’t yet have a plan in place for safe medication storage in your home, it’s time to create one for the health and safety of your loved ones, and for your own peace of mind.

*Keep in mind that this is a suggested starting point for your medication safety plan, not a complete list.

This post was originally published in 2022. It was updated in 2026 to reflect the latest information about safe medication storage.

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